Can metformin be used as a treatment for unresponsive oral ulcers? A case report

Abstract

Introduction: Aphthae are common lesions that occur inside the mouth on the mucous membrane, often associated with various diseases. The causal pathogenesis generally depends on the accompanying condition, but there is usually no serious underlying cause. Case presentation: This case report describes a 33-year-old male patient with a 10-year history of recurrent oral ulcers and impaired glucose tolerance. The patient had previously been treated with glucocorticoids, which provided temporary relief. Laboratory tests and immune profiles were normal. After 1 week of treatment with metformin at a dose of 500 mg twice daily, the lesions were relieved, and the patient required further metformin treatment for three years without any recurrence. Discussion: Metformin has been shown to have anti-inflammatory effects in preclinical studies, making it a potential treatment option for mucocutaneous manifestations. This case report highlights the clinical effectiveness of metformin in treating oral ulcers and suggests its potential as an alternative treatment option for this condition. Conclusion: Further studies are needed to confirm the efficacy and safety of metformin in treating mucocutaneous manifestations.