Abstract
Can 3D-domain-swapping help understand polyQ sequences? Proteins with expanded polyQ repeats can form neurological disease-associated amyloids. The regions surrounding the polyQ sequences are often not resolved in 3D structures. Thus, understanding the structural details of polyQ stretches even in non-amyloid contexts may provide insight into the mechanism of amyloidogenesis. Previous work on the chymotrypsin inhibitor 2 (CI2) and ribonuclease A (RNase-A) has shown that insertion of polyQ stretches can induce 3D-domain-swapping in proteins.
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