Abstract
Muscarinic receptor inhibition of cAMP-dependent inotropic effects is presumed enhanced in congestive heart failure (CHF). Muscarinic receptors constitutively inhibit cAMP formation in normal rat cardiomyocytes. We studied whether increased muscarinic constitutive inhibition modulates beta-adrenergic (βAR) and 5-HT4 serotonergic inotropic effects in CHF. Contractility was measured in papillary muscles and adenylyl cyclase (AC) activity in ventricular membranes from rats with post-infarction CHF or sham-operated controls (Sham).
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