Abstract
This report provides data related to the safety and effectiveness of repeated time-varying caloric vestibular stimulation (CVS) as a treatment for motor and non-motor features of Parkinson's disease (PD). Forty-six subjects receiving stable anti-Parkinsonian therapy were randomized to active (n = 23) or placebo (n = 23) treatment arms. Subjects self-administered CVS twice-daily over a period of 8 weeks at home via a portable, pre-programmed, solid-state ThermoNeuroModulation (TNM™) device delivering continually-varying thermal waveforms through aluminium ear-probes mounted on a wearable headset. Change scores from baseline to end of treatment and to a 1-month follow-up were determined using standardized clinical measures. The data presented here report sample demographics, detailed safety data and the statistical outcomes from the intention-to-treat and modified intention-to-treat analyses. These data supplement findings of the main per protocol analysis reported in the allied article entitled, ‘Caloric Vestibular Stimulation for the Management of Motor and Non-Motor Symptoms in Parkinson's Disease’ Wilkinson et al.
Highlights
A recent case study showed that repeated sessions of caloric vestibular stimulation (CVS) relieved motor and non-motor symptoms associated with Parkinson's disease (PD)
CVS was self-administered at home via a portable, solid-state, device that discharged time-varying thermal waveforms via ear pieces housed in a headset [2]
This result builds on evidence from laboratory experiments showing that vestibular stimulation in PD can increase functional neural connectivity and improve certain aspects of motor control [3,4,5,6,7,8,9]
Summary
A recent case study showed that repeated sessions of caloric vestibular stimulation (CVS) relieved motor and non-motor symptoms associated with Parkinson's disease (PD). CVS was self-administered at home via a portable, solid-state, device that discharged time-varying thermal waveforms via ear pieces housed in a headset [2] This result builds on evidence from laboratory experiments showing that vestibular stimulation in PD can increase functional neural connectivity and improve certain aspects of motor control [3,4,5,6,7,8,9]. Together, these data prompted the current double-blinded, placebo-controlled study which sought to determine whether CVS might provide lasting, clinically-relevant improvement of both motor and non-motor features of PD
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