Abstract
The effect of phospholipid liposomes on solid phase induction from metastable calcium phosphate solutions was evaluated. Dioleoylphosphatidate liposomes catalyzed formation of apatite in the presence of carbonate and octacalcium phosphate when carbonate was absent. Dioleoylphosphatidylglycerol liposomes did not induce solid phase formation. The phosphatidate molecules had to be packed into an extended lamellar phase in order to function as a catalyst. The study indicates that the dioleoylphosphatidate bilayer presents an electrostatic grid in which Ca 2+ binding and subsequent Ca·PO 4 ion pairing provide nidi for crystal formation and growth. Acidic phospholipid microdomains in situ could provide similar catalytic sites.
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