Abstract
CAF-specific markers: role of the TGFβ pathway.
Highlights
TGFβ is a pleiotropic cytokine with potent antimitogenic and pro-apoptotic effects and is further regulating epithelial-mesenchymal transition (EMT), motility and cell differentiation
Due to the dual function of TGFβ as a tumorsuppressor and tumor-promotor, it is paramount to fully elucidate context-dependent TGFβ-mediated actions and it is pivotal that the role of critical tumor microenvironmental factors such as the presence and role of cancer-activated fibroblasts (CAFs) is fully understood
TGFβ is a major player in the tumor-stromal crosstalk as it is a known key factor inducing transdifferentiation of fibroblasts into activated fibroblasts, a phenotype that has been linked to CAFs
Summary
TGFβ is a pleiotropic cytokine with potent antimitogenic and pro-apoptotic effects and is further regulating epithelial-mesenchymal transition (EMT), motility and cell differentiation. Due to the dual function of TGFβ as a tumorsuppressor and tumor-promotor, it is paramount to fully elucidate context-dependent TGFβ-mediated actions and it is pivotal that the role of critical tumor microenvironmental factors such as the presence and role of cancer-activated fibroblasts (CAFs) is fully understood.
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