Abstract
Cyclic ADP-ribose (cADPR) is the most potent Ca 2+-mobilizing agent known. It has been found in many different cell types, where it is synthesized from its precursor NAD + by ADP-ribosyl cyclases. cADPR binds to Ca 2+ channels in the endoplasmic reticulum membrane to activate a Ca 2+-release mechanism. This release is itself potentiated by elevated cytoplasmic Ca 2+ concentrations. Thus, cADPR may function as an endogenous regulator of Ca 2+-induced Ca 2+ release, and there is excitement that it may also function as a Ca 2+-mobilizing second messenger.
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