Biochemical and biophysical research communications | VOL. 607

C-MYC-USP49-BAG2 axis promotes proliferation and chemoresistance of colorectal cancer cells invitro.

Publication Date Jun 4, 2022


Deubiquitinases (DUBs) play critical roles in tumorigenesis and are emerging as potential therapeutic targets. However, it remains less clear which DUBs may play important roles and represent a realistic vulnerability for a particular type of tumor. Here we revealed that Ubiquitin Specific Peptidase 49 (USP49) is transcriptionally activated by c-MYC in colorectal cancer (CRC), and CRC patients with elevated USP49 levels exhibited significantly shorter survival. Knockdown of USP49 markedly inhibited CRC cell proliferation, colony formation, and chemotherapy resistance invitro. Investigation of mechanisms unravels that USP49 deubiquitinates and stabilizes Bcl-2-Associated Athanogene 2 (BAG2), a well-known protein that antagonizes apoptosis and enables adaptive response of CRC cells. This study identified a novel mechanism by which USP49 promotes CRC cell survival by stabilizing BAG2 through the c-MYC-USP49-BAG2 axis, indicating that USP49 may become a potential therapeutic target for CRC.


Bcl-2-associated Athanogene 2 Chemoresistance Of Colorectal Cancer Cells Colorectal Cancer Potential Therapeutic Target For Colorectal Cancer Colorectal Cancer Cell Particular Type Of Tumor Deubiquitinases Colorectal Cancer Cell Proliferation Colorectal Cancer Patients Type Of Tumor

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