Biochemical and biophysical research communications | VOL. 607
Read

C-MYC-USP49-BAG2 axis promotes proliferation and chemoresistance of colorectal cancer cells invitro.

Publication Date Jun 4, 2022

Abstract

Deubiquitinases (DUBs) play critical roles in tumorigenesis and are emerging as potential therapeutic targets. However, it remains less clear which DUBs may play important roles and represent a realistic vulnerability for a particular type of tumor. Here we revealed that Ubiquitin Specific Peptidase 49 (USP49) is transcriptionally activated by c-MYC in colorectal cancer (CRC), and CRC patients with elevated USP49 levels exhibited significantly shorter survival. Knockdown of USP49 markedly inhibited CRC cell proliferation, colony formation, and chemotherapy resistance invitro. Investigation of mechanisms unravels that USP49 deubiquitinates and stabilizes Bcl-2-Associated Athanogene 2 (BAG2), a well-known protein that antagonizes apoptosis and enables adaptive response of CRC cells. This study identified a novel mechanism by which USP49 promotes CRC cell survival by stabilizing BAG2 through the c-MYC-USP49-BAG2 axis, indicating that USP49 may become a potential therapeutic target for CRC.

Concepts

Bcl-2-associated Athanogene 2 Chemoresistance Of Colorectal Cancer Cells Colorectal Cancer Potential Therapeutic Target For Colorectal Cancer Colorectal Cancer Cell Particular Type Of Tumor Deubiquitinases Colorectal Cancer Cell Proliferation Colorectal Cancer Patients Type Of Tumor

Round-ups are the summaries of handpicked papers around trending topics published every week. These would enable you to scan through a collection of papers and decide if the paper is relevant to you before actually investing time into reading it.

Climate change Research Articles published between Nov 14, 2022 to Nov 20, 2022

R DiscoveryNov 21, 2022
R DiscoveryArticles Included:  2

The world needs to move quickly towards sustainability that should characterize all production and consumption patterns. We use cookies to improve you...

Read More

Coronavirus Pandemic

You can also read COVID related content on R COVID-19

R ProductsCOVID-19

ONE PROBLEM . ONE PURPOSE . ONE PLACE

Creating the world’s largest AI-driven & human-curated collection of research, news, expert recommendations and educational resources on COVID-19

COVID-19 Dashboard

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on “as is” basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The Copyright Law.