Abstract
A digital microfluidic biochip is an attractive platform for revolutionizing immunoassays, clinical diagnostics, drug discovery, DNA sequencing, and other laboratory procedures in biochemistry. A recent generation of biochips uses a microelectrode-dot-array (MEDA) architecture, which provides finer controllability of droplets and seamlessly integrates microelectronics and microfluidics using CMOS technology. In order to simplify the wiring problem for MEDA biochips, all microelectrodes and their control registers are daisy-chained together. Therefore, chain diagnosis and fault tolerance are critical for MEDA biochips. We propose the first daisy-chain design that can perform self-diagnosis and repair the detected faults. In our design, every microelectrode cell is fully controlled, and faults in the daisy chain can be detected and repaired in a timely manner. Moreover, the proposed design can be used in both online and off-line modes. Experimental results demonstrate the effectiveness of the proposed daisy-chain design.
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