Abstract
Background: Body fat distribution is a risk factor for several health conditions, although the literature shows that excess body fat is not always associated with cardiometabolic abnormalities in all subjects.Objectives: To investigate glucose, lipid, and hepatic metabolism, along with white (WAT) and brown adipose tissue (BAT) remodeling in a mice model of short-term fructose feeding.Methods: Male C57BL/6 mice (n = 10-11/group) were fed for four weeks with control diet (AIN93-M) or experimental diets rich in glucose or fructose. We investigated body weight, body adiposity, blood glucose, lipid and hepatic parameters, and WAT and BAT histopathology.Results: Fructose feeding did not promote either weight gain or adipocyte hypertrophy of visceral and subcutaneous WAT depots, but the fat was redistributed toward visceral depots. Fructose-fed mice did not show glucose, lipid, and hepatic metabolic dysfunction, except for an elevation in total cholesterol and hepatic weight. BAT mass did not increase, and it was proportionally reduced compared with visceral WAT in fructose feed mice. BAT suffered early adverse morphological remodeling, characterized by increased lipid deposition and enlargement of intracellular lipid droplets.Conclusion: Short-term fructose feeding redistributes fat among WAT depots, alters the ratio between BAT andvisceral WAT, and promotes BAT adverse remodeling, characterized by enlarged intracellular lipid droplets.
Highlights
Obesity is strongly associated with health problems [1], excess body fat is not always associated with cardiometabolic abnormalities, such as insulin resistance, low-grade inflammation, and dyslipidemia
Despite glucose and fructose diets were isoenergetic compared to the control diet, table 2 shows that the cumulative food intake (FI) of fructose group was 10% lower than the control group (P < 0.02)
Energy efficiency reduced by 63% and 87%, respectively, in the glucose and fructose groups (P < 0.0001)
Summary
Obesity is strongly associated with health problems [1], excess body fat is not always associated with cardiometabolic abnormalities, such as insulin resistance, low-grade inflammation, and dyslipidemia. The product of fasting triglycerides and glucose (TyG) is a useful index to assess both insulin resistance and hepatic steatosis/nonalcoholic steatohepatitis (NASH) in apparently healthy subjects [6,7] It could be used as an additional early marker of metabolic dysfunction in MONW individuals. Objectives: To investigate glucose, lipid, and hepatic metabolism, along with white (WAT) and brown adipose tissue (BAT) remodeling in a mice model of short-term fructose feeding. Conclusion: Short-term fructose feeding redistributes fat among WAT depots, alters the ratio between BAT and visceral WAT, and promotes BAT adverse remodeling, characterized by enlarged intracellular lipid droplets
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
