Abstract
Objective To compare bronchodilation effects of inhaled budesonide/formoterol (dose:100 μ g and 6 μ g) and budesonide (100 μ g)/salbutamol (100 μ g) for the 5-15 year-old children with asthma exacerbation.Methods A double-blind randomized controlled trial was conducted each MDI intervals,children were administered two times,receiving formoterol or salbutamol,both groups received 100 μ g of budesonide.At 20-minute intervals,all children received three doses of the drug.Analysis and comparison of FEV1 (％ predicted)and the amendments to the pulmonary index score (MPIS) were analyzed.Efficacies of 1,5,15,30,60 minutes were studied.Results FEV1(％ predicted) and MPIS had no significant differences.From 1 minute to 60 minutes,one minute after administration,FEV1 (％ predicted),formoterol and salbutamol from baseline were significantly improved.Peak expiratory flow rate (PEFR),percentage of predicted PEFR,forced expiratory flow 50 (FEF50) and percentage of predicted FEF50 were significantly improved.At different time points,the two groups were similar during the study and were not statistically significant.Conclusions In a certain inhaled dose,mild acute asthma among 5-15 years children,salbutamol or formoterol have a similar bronchodilator effect. Key words: Acute asthma; Bronchodilatation; Formoterol; Salbutamol
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