Abstract
Though biocompatible small-molecule-based NIR-II fluorescent nanoparticles (NPs) are highly desirable in fluorescence imaging (FI), the fluorescence quantum yield is relatively poor due to the significant aggregation-caused quenching and the heavy intermolecular interactions. Herein, we conveniently obtained bright NIR-II fluorescent small-molecule NPs (TQFPNs) fabricated from a polystyrene (PS)-modified fluorophore (TQF-PS). Our prepared PS-modified NPs displayed 3.2-fold higher emission intensity than that of non-PS polymer chain NPs (TQF@NPs) in vitro. Finally, bright and high-resolution NIR-II FI of a rheumatoid arthritis mouse model and a pneumonia mouse model using TQFPNs demonstrated its successful application for targeted in vivo inflammation imaging.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
