Abstract
Background: Anti-inflammatory and antioxidant activities are the main pathways of neuroprotective drugs. Bridelia atroviridis possesses those activities and is empirically used by Cameroonian traditional healers to alleviate memory and mood disorders.
 Objective: The purpose of this study is to evaluate the anti-amnesic and antidepressant effects of Bridelia atroviridis aqueous extract (EA).
 Methods: Scopolamine was used to induce amnesia and depression in rats. Administrated per os, three doses of EA, including 36, 72, and 144 mg/kg, were used. Behavioral disorders were evaluated through novel object recognition, the Morris water maze, forced swimming, and an open arena. The oxidative stress markers, like malondialdehyde, reduced glutathione, and nitrite levels in the brain, were measured. Neurometabolites, serotonin, and acetylcholine levels were determined. Hematoxylin-eosin paraffin-embedded histological sections were used to assess neuron viability in the cortex and the hippocampus.
 Results: Pre-treatments with EA attenuated the deleterious effects of scopolamine and improved brain biomarkers. Indeed, when compared to vehicle control, Bridelia atroviridis increased Ca2+, Mg2+, serotonin, and acetylcholine levels in the brain. Furthermore, the plant reduced significantly (p < 0.001) the recognition index in the novel object recognition test and increased (p < 0.001) the time spent in the target quadrant in the Morris water maze test. Besides, EA has scavenging activities and attenuates neuron death in the cortex and hippocampus.
 Conclusion: According to this study, the aqueous extract of B. atroviridis barks protects against scopolamine-induced memory loss and depressive disorders. The preventive activities of the plant involve cholinergic and monoaminergic pathways and antioxidant potential.
 Graphical Abstract: 
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