Abstract
A breeding study was performed from the viewpoint of biochemical engineering to obtain strains which produce bialaphos (a herbicide) with high productivity and high yield from inexpensive substrates under low oxygen supply, with good filtration efficiency and easy downstream treatment. After induing mutagenesis using conventional chemical mutagens, first selection on agar culture was made to obtain strains which exhibited a large inhibition zone with a small colony, without being influenced by carbon catabolite regulation and with suppression of product decomposition. Subsequently, in a liquid culture system, selection was made to obtain strains which exhibited high product concentrations under low oxygen supply, with good filtration efficiency. A strain thus obtained was found to have about five hundred times higher product concentration than the wild strain. It also enabled us to use an inexpensive carbon source and to produce bialaphos under low oxygen supply, with good filtration efficiency.
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