Abstract

Breast cancer is one of the worst illnesses, with a higher fatality rate among women globally. Breast cancer detection needs accurate mammography interpretation and analysis, which is challenging for radiologists owing to the intricate anatomy of the breast and low image quality. Advances in deep learning-based models have significantly improved breast lesions’ detection, localization, risk assessment, and categorization. This study proposes a novel deep learning-based convolutional neural network (ConvNet) that significantly reduces human error in diagnosing breast malignancy tissues. Our methodology is most effective in eliciting task-specific features, as feature learning is coupled with classification tasks to achieve higher performance in automatically classifying the suspicious regions in mammograms as benign and malignant. To evaluate the model’s validity, 322 raw mammogram images from Mammographic Image Analysis Society (MIAS) and 580 from Private datasets were obtained to extract in-depth features, the intensity of information, and the high likelihood of malignancy. Both datasets are magnificently improved through preprocessing, synthetic data augmentation, and transfer learning techniques to attain the distinctive combination of breast tumors. The experimental findings indicate that the proposed approach achieved remarkable training accuracy of 0.98, test accuracy of 0.97, high sensitivity of 0.99, and an AUC of 0.99 in classifying breast masses on mammograms. The developed model achieved promising performance that helps the clinician in the speedy computation of mammography, breast masses diagnosis, treatment planning, and follow-up of disease progression. Moreover, it has the immense potential over retrospective approaches in consistency feature extraction and precise lesions classification.

Highlights

  • Breast cancer is threatening malignancy and the leading cause of cancer-related mortality in women’s community, with an increased 6.6% to 6.9% mortality rate in the current year [1, 2]

  • This study proposes the contrast limited adaptive histogram equalization (CLAHE) method to enhance the overall quality of mammography images [35]

  • The proposed method was designed based on scientific methodology to predict breast masses using mammography images

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Summary

Introduction

Breast cancer is threatening malignancy and the leading cause of cancer-related mortality in women’s community, with an increased 6.6% to 6.9% mortality rate in the current year [1, 2]. This high death rate is primarily due to delayed malignancy detection. Breast masses vary in intensity, distribution, shape (lobulated, irregular, round, oval) and boundary (spiculated, ill-defined, circumscribed) within the breast region, which increases the likelihood of misdiagnosis [4]. Breast cancer is categorized as malignant when tumors are irregularly shaped, have ambiguous edges, and blurred boundaries; on the other hand, benign masses are often dense, well-defined circumscribed, and roughly spherical. As a result of the heterogeneity, morphological diversity, confusing boundaries, and varying cancerous cell sizes, doctors have difficulty recognizing malignant tumors, resulting in needless biopsies

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