Abstract
Experiment 1 identified the neuroanatomical projections associated with an area of frontal cortex of rats previously shown to produce retrograde amnesia (RA) when electrically stimulated. Nauta-Gygax and Fink-Heimer stains suggested that the frontal cortical region studied was in part motor cortex. In addition to the motor projection leaving this area, many fibers in the cerebral peduncle collateralized at the level of the substantia nigra and projected to various regions in the limbic midbrain. Experiment 2 investigated the effects of posttrial bilateral electrical stimulation of the midbrain on retention of a one-trial inhibitory avoidance response. Primary afterdischarge activity initiated in the midbrain and propagated to the cortex did not result in amnesia. Amnesia did result, however, when midbrain stimulation led to the production of both a primary afterdischarge and a subsequent spontaneous secondary afterdischarge.
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