Abstract
The organ specific, acidic and soluble proteins of the brain especially, S-100, NP, 14−3−2, α2-glycoprotein and Olfactory bulb protein have been reviewed. These are the products of specific cell types and may be distributed in the specific regions of the brain. All of them are organ specific but species non-specific. A number of cell lines derived from human and animal brain tumours synthesize S-100, NP and 14−3−2 proteins. The temporal relationship of S-100, NP and 14−3−2 with the maturation of many of the physiological events and their involvement in the regulatory and learning processes indicate that these are important functional proteins in the brain.
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