Abstract
Abstract Brain-smooth muscle (BSM) axis refers to a bidirectionally influencial and modulatory pathway between the encephalic region and smooth muscle. Via a local cytochrome P450 enzyme and an endogenous active material, stress reaction between the brain and vascular or visceral smooth muscle was modulated, specially implicated depressive comorbidities. Evidence provided by publications and recent experiments of this research group showed that firstly, 40%–50% depression is comorbidity of functional gastrointestinal disorders; a frequent comordibity of functional hypothalamus amenorrhea and depression; depression increases 3- to 6-fold of nocturia than in healthy people; myocardial and cerebral ischemia induce depression. Comorbidity just mentioned especially refers to simultaneous disorders of the brain and vascular or visceral smooth muscle. Secondly, a traditional Chinese medicine formula is as effective as an anti-depressive, prokinetic and vasoactive, which highlights the therapeutic mechanism of modern anti-depressive serotonin and noradrenaline reuptake inhibitors. Absorbed bioactive compounds in hippocampus, intestine and vessel wall were detected after oral administration of the formula and forced swimming rat. Thirdly, both sides of the BSM axis are the same, suggesting the common pathophysiological mechanism. Among the four axes, only “brain”, one side of the axis, is the same and the other sides are different. Fourthly, the pivotal role is that one of the important pathogenetic mechanisms involved in liver visceral manifestation of TCM theory and stress disease is the disorder of the BSM axis. The validation and improvement of the BSM axis hypothesis contribute much to the study of depression, stress diseases and liver visceral manifestation in TCM.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.