Abstract
This article discusses the role of brain neurotrophic factors (NTFs) in the development of the syndrome of psychological addiction to psychoactive substances. The data on the impairments of NTF metabolism after acute and chronic drug action are summarized. The changes in the addictive activity of psychoactive substances were analyzed in rodents with defective genes for neurotrophic factors and under conditions of modified metabolism of the examined regulatory proteins. We concluded that the brain-derived neurotrophic factor may enhance the addictive potential of cocaine. The glial neurotrophic factor and tumor necrosis factor-α show anti-addictive activities during consumption of cocaine, methamphetamine, morphine, and ethanol. The brain-derived neurotrophic factor inhibits the development of psychological addiction to ethanol. The leucine-isoleucine dipeptide increases the concentration of glial neurotrophic factor and tumor necrosis factor-α in the mouse brain and, thus, suppresses the formation of psychological addiction to methamphetamine and morphine. The possible use of these substances in narcological clinical practice is discussed.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
