Abstract
AbstractGlaucoma is one of the leading causes of blindness worldwide. The mechanisms underlying glaucomatous involvement of the central nervous system are still not completely known. It has been hypothesized that glaucomatous degeneration may be the result of anterograde transsynaptic neurodegeneration triggered by ganglion cells' death. However, it has been also postulated that in some cases it may be the consequence of neurodegenerative diseases of the central nervous system such as Alzheimer's' Disease. Autophagy and perfusion deficits have been also implicated in the etiopathogenesis of glaucoma. The introduction of new neuroimaging techniques may help to extend the knowledge about this disease, consent early diagnosis and could be a valuable tool for assessing the therapeutic efficacy of novel neuroprotective strategies.
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