Abstract
The effect of icatibant, a selective bradykinin receptor (B2) antagonist on myocardial ischemic–reperfusion injury was studied in open-chest barbiturate anaesthetized cats. Left anterior descending coronary artery was occluded for 15 min, followed by 60 min of reperfusion. Saline or icatibant (200 μg/kg) was administered intravenously slowly over 2 min, 5 min before reperfusion. In the saline-treated group, myocardial ischemic reperfusion injury was evidenced by depressed mean arterial pressure (MAP), peak positive and negative dP/dt and elevated left ventricular end-diastolic pressure and enhanced oxidant stress [elevated TBARS (thiobarbituric acid reactive substances; a marker for lipid peroxidation), depressed GSH (glutathione), SOD (superoxide dismutase), catalase] and depletion of ATP.
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