Abstract
Chinese jujube which contains many nutrients, contributes to a healthy diet. Jujube pulp extracts are rich in polyphenol compounds exhibiting admirable pharmacological activities. In present, free and bound polyphenols extracted from jujube pulp were named JPFP and JPBP, respectively. Interesting, we found only JPBP exhibited prominent anti-tumor activity in HepG2 cells, and especially, it also had the same effect in nude mice tumor model. Further, the study showed that p-Coumaric acid and ferulic acid might be main active components in JPBP. Mechanically, JPBP decreased mitochondrial membrane potential (MMP) via blocking AKT/NF-κB/Bcl-2 signal axis. Subsequently, the decrease of MMP induced mitochondria-mediated intrinsic apoptotic pathway and the overproduction of intracellular ROS in HepG2 cells, which contributed to cell apoptosis. Meantime, JPBP suppressed cell proliferation through promoting HepG2 cell cycle arrest in S phase. Collectively, this study sheds light on the potential application of JPBP on the prevention and therapy of hepatocellular carcinoma.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
