Abstract
Objective To investigate the cytotoxic effect of bortezomib(BTZ)on human cutaneous T-cell iymphoma Hut-78 cell line and the antitumor activity of BTZ combined with pirarubicin(THP)on tumor cells.Methods The effects of BTZ,THP alone,or BTZ plus THP,on the proliferation of Hut-78 cells were determined by MTr assay.Results BTZ and THP alone effectively induced growth inhibition of Hut-78 cells in a time-and dose-dependent manner,with an 50 % inhibiting concentration of 8.53 nmol/L and 2515.27 μg/L individually after 48 hours of culture.BTZ plus THP had an impressive antitumor efficacy compared with single agent.The combination index analysis showed significant synergistic effects when treated with BTZ followed by THP and concurrent BTZ plus THP,especially for the former.Conclusion BTZ alone or combined with THP significantly inhibited the growth of Hut-78 cells in vitro.Our study demonstrated that BTZ plus THP presents a synergistically antitumor effect on T cell lymphoma cells and may be an optimal regimen in clinical trial of T cell lymphoma. Key words: Lymphoma,T-cell; Cell line,tumor; ,Ceil proliferation; Depression,chemical; Drug antagonism
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
