Abstract
In this article, a novel method of simultaneous carborane- and gadolinium-containing compounds as efficient agents for neutron capture therapy (NCT) delivery via magnetic nanocarriers is presented. The presence of both Gd and B increases the efficiency of NCT and using nanocarriers enhances selectivity. These factors make NCT not only efficient, but also safe. Superparamagnetic Fe3O4 nanoparticles were treated with silane and then the polyelectrolytic layer was formed for further immobilization of NCT agents. Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), energy dispersive X-ray (EDX), ultraviolet–visible (UV-Vis) and Mössbauer spectroscopies, dynamic light scattering (DLS), scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM) were applied for the characterization of the chemical and element composition, structure, morphology and magnetic properties of nanocarriers. The cytotoxicity effect was evaluated on different cell lines: BxPC-3, PC-3 MCF-7, HepG2 and L929, human skin fibroblasts as normal cells. average size of nanoparticles is 110 nm; magnetization at 1T and coercivity is 43.1 emu/g and 8.1, respectively; the amount of B is 0.077 mg/g and the amount of Gd is 0.632 mg/g. Successful immobilization of NCT agents, their low cytotoxicity against normal cells and selective cytotoxicity against cancer cells as well as the superparamagnetic properties of nanocarriers were confirmed by analyses above.
Highlights
Cancer disease remains the second leading cause of death worldwide due to it aggressiveness and treatment difficulty
The surface was functionalized according to Scheme 1 with C=C double bonds via the polycondensation reaction with 3-(trimethoxysilyl)propyl methacrylate (TMSPM)
It is based on the removal of CH3O- from alkoxysilane and attaching it to the OH group of Fe3O4 nanoparticles
Summary
Cancer disease remains the second leading cause of death worldwide due to it aggressiveness and treatment difficulty. One of the traditional methods to treat cancer is chemotherapy, but because of its damage to normal cells surrounding the tumor it can lead to consequences, such as cardio toxicity, neurotoxicity, infertility, nephropathy, and chronic liver damage [1,2,3]. Over the last two decades, the attention paid to cancer disease has increased, and plenty of theoretical and engineering research has been conducted. Neutron capture therapy (NCT) has shown promising results in treating glioblastoma and some other radioresistant tumors. This method can be characterized by its high selectiveness and the effectiveness of treatment [10]
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