Abstract
Boragen, the first start-up to launch from a new business accelerator focused on agriculture technology, has raised $10 million in its first round of venture funding. The firm will use the money to develop synthetic fungicides based on a group of boron-containing compounds. Cofounder and chief science officer Tony Liu, a synthetic chemist, first zeroed in on a group of compounds called benzoxaboroles while screening for pharmaceutical leads. Benzoxaboroles have been used in topical antibiotics and antifungals. “Boron is a unique building block that allows a lot of freedom to modulate geometry and charge,” Liu points out. “You can fine-tune the reactivity by changing what you put around it for a specific use.” Boragen’s lead candidate boasts a new mode of fungus-killing action, which will help prevent the emergence of resistant organisms, says CEO John W. Dombrosky. And it can be used in tiny amounts when combined with common fungicides,
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