Abstract
There is a high prevalence of diabetes mellitus type-2 (T2DM) and osteoporosis are problems worldwide. In this study, we evaluated the correlation between T2DM and bone turnover in diabetic obese postmenopausal Saudi women. The present study included total of 65 T2-DM obese postmenopausal Saudi women, (36 uncontrolled, 29 controlled). The following serum biochemical parameters were evaluated [fasting blood glucose (FBG), total calcium (Ca), phosphorus (Pi), parathyroid hormone (PTH), 1,25-(OH)2 Vitamin D3, osteocalcin (OC), procollagen (PICP) and cathepsin k (Cath K)]. Serum OC levels were significantly decreased in diabetic obese postmenopausal group compared to their respective healthy group (P < 0.004). PICP and Cath K were significantly elevated in diabetic postmenopausal group compared to the healthy group (P < 0.024 & 0.001). A significant elevation in 1,25(OH)2 Vitamin D3, Ca and Pi levels in diabetic obese postmenopausal patients group compared to the healthy group. However, a non-significant changes was observed in serum PTH level between different groups. In this study, the changes in the biochemical parameters and bone turnover markers in obese women are strong risk factors for diabetes development that may contribute to osteopenia and osteoporosis. The study showed the strong effect of T2DM on biochemical markers of bone turnover in obese postmenopausal Saudi women.
Highlights
Type-2 diabetes mellitus (T2DM) is a worldwide pandemic and World Health Organization (WHO) predicts that the current figure of 170 million affected patients with diabetes will be more than double, to 370 million patients by the year 20301
Analysis of data by analysis of variance (ANOVA) indicated a significant differences in mean values between groups for each of BMI, fasting blood glucose, glycosylated hemoglobin, systolic and diastolic blood pressure ( P < 0.001, 0.0001, 0.0001,0.032 and 0.022 respectively)
The evidence supporting that vitamin D level is important to regulate some pathways related to type 2 diabetes development[10], due to vitamin D which is important for insulin synthesis and release
Summary
Type-2 diabetes mellitus (T2DM) is a worldwide pandemic and World Health Organization (WHO) predicts that the current figure of 170 million affected patients with diabetes will be more than double, to 370 million patients by the year 20301. The structure of the mature adult skeleton is the result of different cellular mechanisms These are endochondral and intramembranous ossification together with modeling and remodeling on preformed surfaces. We evaluated the correlation between T2DM and bone turnover in diabetic obese postmenopausal Saudi women. Subjects and Methods: The present study included total of 65 T2-DM obese postmenopausal Saudi women, (36 uncontrolled, 29 controlled) .The following serum biochemical parameters were evaluated [fasting blood glucose (FBG),total calcium (Ca), phosphorus (Pi), parathyroid hormone (PTH), 1,25-(OH)2Vitamin D3 ,osteocalcin (OC), procollagen (PICP) and cathepsin k (Cath K) ]. Conclusion: In this study, the changes in the biochemical parameters and bone turnover markers in obese women are strong risk factors for diabetes development that may contribute to osteopenia and osteoporosis. The study showed the strong effect of T2DM on biochemical markers of bone turnover in obese postmenopausal Saudi women.
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