BONE METASTASIS AFTER AN OPERATION FOR A BREAST CANCER FOR WHICH ADMINISTRATION OF LH-RH AGONIST WAS EFFECTIVE -REPORT OF A CASE

Abstract

Breast cancer is a hormone dependent disease, and the usefulness of surgical ovariectomy had been established. After that, endocrine therapy has greatly advanced. In January, 1994, indication of goserelin acetate, a LH-RH agonist, for premenopausal women with breast cancer was approved, and is expected to be an alternative of surgical ovariectomy. In this paper our experience with an postoperative case of breast cancer with bone metastasis, in which the usefulness of LH-RH agonist regimen was able to confirm by a long-term observation, is presented with a review of the literature. A 53-year-old premenopausal women had a metastasis to the right intertrochanter of the femur one year and 11 months after an operation for a right breast cancer (T2aN0M0, Stage II). The bone not respond to chemotherapy. So administration of LH-RH agonist was started and CR was attained after one year. Two years later new metastatic lesion was detected in the first lumber vertebra and the patient was reted as PD. Radiation therapy at 40 Gy was added. There has been no sign of recurrence, as of 6 years and 10 months after the operation for the breast cancer or 4 years and 11 months after the first diagnosis of bone metastasis.