Abstract
Abstract Ghoshy et al. in their recent review in European Journal of Haematology (1) tried to present data about the prevalence of low bone mineral density (BMD) in patients with haemophilia A and B and analyze the pathophysiology of this entity proposing appropriate management. The authors report data of small studies and refer mainly to the association of low BMD with hepatitis C (HCV) and human immunodeficiency virus (HIV) infections and their treatment (interferon-α, anti-retroviral therapy). They also refer to the possible role of vitamin K and the interaction between factor VIII-von Willebrand and receptor activator of nuclear factor-κB (RANK) ligand (RANKL), in the induction of osteoclastogenesis (1). © 2013 John Wiley a Sons A/S.
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