Abstract
Medication-related osteonecrosis of the jaw (MRONJ) is one of the most serious side effects resulting from treatment with antiresorptive and antiangiogenic drugs used to treat diseases such as malignant tumors. In 7 cases clinically diagnosed with MRONJ, bone alterations were viewed through Cone-Beam Computed Tomography (CBCT), analyzing the quadrants with bone necrosis and the other quadrants with no clinical diagnosis. Therefore, the following characteristics were consistently observed in both the affected quadrant and those considered to be healthy: periodontal ligament thickening, osteosclerosis, thickening of the basal mandibular cortical, osteolytic areas, thickening of the dental lamina dura, and persistent alveolus. Two or more imaging bone changes identified in the CBCT images occurred in at least in one contralateral quadrant, leading to a suggestion that the bone alterations might occur equally in the entire maxillo-mandibular complex. Medication-related osteonecrosis of the jaw (MRONJ) is one of the most serious side effects resulting from treatment with antiresorptive and antiangiogenic drugs used to treat diseases such as malignant tumors. In 7 cases clinically diagnosed with MRONJ, bone alterations were viewed through Cone-Beam Computed Tomography (CBCT), analyzing the quadrants with bone necrosis and the other quadrants with no clinical diagnosis. Therefore, the following characteristics were consistently observed in both the affected quadrant and those considered to be healthy: periodontal ligament thickening, osteosclerosis, thickening of the basal mandibular cortical, osteolytic areas, thickening of the dental lamina dura, and persistent alveolus. Two or more imaging bone changes identified in the CBCT images occurred in at least in one contralateral quadrant, leading to a suggestion that the bone alterations might occur equally in the entire maxillo-mandibular complex.
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