Abstract
In children with RDS, the concomitant respiratory-metabolic acidosis leads with the Bohr effect to a lowering of oxygen affinity (increases of P<sub>50</sub>).However, pH reduction and resultant lowering of 2,3-DPG concentration in the erythrocytes make one expect an oxygen affinity increase. The question is thus to what extent the two influences overlap and neutralize each other. We wanted to take a look at this problem as part of a more extensive study, and so we measured the acid-base status, the oxygen affinity of hemoglobin, the 2,3-DPG, ATP, ADP and AMP contents in the blood of premature infants with RDS and in some term infants with RDS; then we compared these measurements with those of premature infants without RDS.
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