Abstract
Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by the decreasing of insulin production due to damage to pancreatic β-cells. Secretome is a substance that found in stem cell media have ability to regeneration cell because contain cytokines and growth factors. The aim of this study was to determine the role of the secretome in regenerating pancreatic cells to increase body weight in rat with diabetes mellitus type 1. This study used 60 rats and were divided into healthy control group; diabetes mellitus group; treatment group was induced with streptozotocin and injected with a secretome dose of 0.05; 0,1; 0,2 ml/kg body weight intraperitoneally once a week for four weeks intraperitoneally. The body weight of the rats was measured daily using a digital scale for four weeks. The results of this study showed a significant difference in the body weights of each group (p = 0.000). The lowest average body weight was observed in the diabetes mellitus group, whereas the highest average body weight was observed in the healthy control group. In the group that received treatment, the pattern that could be seen was that the more doses given, the more the body weight tended to increase. This study was confirming that there was increasing body weight in diabetes mellitus type 1 that treated with secretome.
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