Abstract
Touch is among the least understood of our senses despite its importance in our daily lives. In the model organism C. elegans, gentle touch is detected by six touch receptor neurons situated in the outer shell of the animal. Force applied to the body is filtered by the outer shell (cuticle, hypodermis and body wall muscles) of the body, locally straining nearby touch receptor neuron(s) and opening mechanically-gated DEG/ENaC channels through an unknown mechanism. Previously we developed a piezoresistive cantilever force clamp system capable of applying calibrated loads to moving C.
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