Body Fatness And Fitness Modulate The Associations Between The Gnb3 Genotype And Resting Blood Pressures In Korean Women

Abstract

Unlike in Caucasians and black Africans, the relationships between the C825T allele variant in exon 10 of the G protein b3 gene (GNB3) and blood pressures are inconsistent in Asians. PURPOSE: To investigate whether or not the GNB3 genotype is differently associated with resting blood pressures and body fatness across cardio/respiratory fitness (CRF) levels. MTHODS: A total of 727 Korean women aged 31-60 years (mean age, 47.8±5.4 yrs old) voluntarily participated in the study. Body fatness and fitness and resting blood pressure were measured by using standardized protocols. The GNB3 genotype (C825T) was determined by using polymerase chain reaction-restriction fragment length polymorphism. RESULTS: For the obese group with body mass index of ≥25 kg/m2, subgroup analyses showed that TT individuals were younger (P =0.049 & P=0.002, respectively) and had significantly higher values in body weight (P=0.006 & P=0.006, respectively) and BMI (P=0.002 & P=0.011, respectively) than CC and CT individuals. Further, TT and CT individuals tended to have higher values in CRF than CC individuals. Regression analyses showed that the relationships between the GNB3 genotype and resting blood pressures remained significant even after adjustments for age and menopause, but the relationships were no longer significant when additionally controlling for body fatness. CONCLUSION: The findings of this study suggest that both body fatness and CRF might differently influence the genetic susceptibility of the GNB3 genotype to elevated resting blood pressures in middle-aged Korean women. Supported by the Korean Research Foundation funded by the Korean Government (KRF-2005-042-G00025)