Blood Volume, Cardiac Size and Renal Function in Dogs with Hypertension Produced by Goldblatt Technic

Abstract

Freeman and Page1 found no significant changes in plasma volume during a period of hypertension experimentally produced by the Goldblatt technic,2 in 3 dogs, 2 of which were completely sympathectomized. We have followed the changes in plasma, cell and total volume by the dye method of Gibson and Evans3,4 in 5 female dogs, none of which were sympathectomized, during periods of hypertension produced by the Goldblatt technic, varying from 1 to 10 months, in an attempt to correlate observed changes in blood volume with changes in mean arterial pressure, renal function and cardiac size as determined by X-ray.Control mean arterial pressure was established by an average of 12 determinations by femoral puncture over a period of 1 month prior to operation. In the operative procedure the renal artery clamp was completely closed and then released 1 to 11/2 turns. Constriction of the right renal artery was effected in each animal first, followed by constriction of the left renal artery at a subsequent operation 2 wee...