Abstract
It has been established that the spontaneously hypertensive rat (SHR) presents an experimental model whose pathogenesis resembles that of essential hypertension in man. A great advantage of this model is that the entire life history of this disease is compressed within a time frame of two years. Many antihypertensive agents have been found effective in reducing blood pressure in SHR animals. Carbon tetrachloride (CCl/sub 4/) treatment has resulted in blood pressure reduction and subsequent elevation after discontinuing treatment in Grollman renal hypertensive rats and in endocrine hypertensive rats. The purpose of this study was to determine whether hypertension in the spontaneously hypertensive rat (SHR), could be modified by CCl/sub 4/ treatment and to evaluate its effects on kidney and liver tissue.
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