Abstract
Purpose: The rapid increase of aged individuals is associated with a concomitant increase in chronic diseases, such as osteoarthritis (OA). A hallmark of such age-related degenerative diseases is the heterogeneous accumulation of senescent cells (SCs) affecting tissues by virtue of a well-defined senescence-associated secretory phenotype (SASP). In this regard, cellular senescence was shown to be a bona fide driver of OA in all stages in mice. Identification of non-invasive reliable biomarkers that sensitively reflect cellular senescence in human articular cartilage is essential to allow efficient monitoring and to evaluate therapy efficacy with e.g.
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