Abstract
Objectives: To observe the bio-distribution and change in blood kinetics of iron chelating drug-desferrioxamine covalently bound to high-molecular weight dialdehyde cellulose. Methods/Statistical Analysis: The DAC-DFO conjugate and free desferrioxamine were labeled with radiotracer 99mTc. In vitro studies, to establish quality control parameters, were performed by instant thin layer chromatography followed by intravenous administration of radio complexes to the rabbits. Gamma camera imaging was carried out and bio-distribution parameters of both conjugate and free drug were evaluated and compared. Findings: Both polymers based and free desferrioxamine samples exhibited > 90% radiolabelling efficiency and a high in-vitro stability. There was significant improvement in blood circulation time after covalent binding of DFO to DAC (at 1500 min) compared to free DFO (at 900 min) After a single injection of 99mTc-DAC-DFO, the highest distribution was observed in the liver at 19.5 minutes with lower uptake in kidneys and urinary bladder till 30min. On the other hand, the highest distribution of free DFO in liver was highest at only 1 minute post-administration. Application/Improvements: The bioavailability of desferrioxamine was found to be enhanced upto several folds after conjugation to oxidized cellulose.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
