Abstract
We read with great interest the article entitled ‘Serum 25-hydroxyvitamin D levels and survival in colorectal and breast cancer patients: Systematic review and meta-analysis of prospective cohort studies’ published in the European Journal of Cancer (Eur J Cancer 2014 May;50(8):1510–1521) [ [1] Maalmi H. Ordonez-Mena J.M. Schottker B. Brenner H. Serum 25-hydroxyvitamin D levels and survival in colorectal and breast cancer patients: Systematic review and meta-analysis of prospective cohort studies. Eur J Cancer. 2014; 50: 1510-1521 Abstract Full Text Full Text PDF PubMed Scopus (112) Google Scholar ]. The meta-analysis by Maalmi et al. was performed to assess the association between blood 25-hydroxyvitamin D [25(OH)D] and survival in patients with colorectal cancer or breast cancer [ [1] Maalmi H. Ordonez-Mena J.M. Schottker B. Brenner H. Serum 25-hydroxyvitamin D levels and survival in colorectal and breast cancer patients: Systematic review and meta-analysis of prospective cohort studies. Eur J Cancer. 2014; 50: 1510-1521 Abstract Full Text Full Text PDF PubMed Scopus (112) Google Scholar ]. They concluded that higher 25(OH)D levels (>75 nmol/L) were associated with significantly reduced mortality in patients with colorectal and breast cancer [ [1] Maalmi H. Ordonez-Mena J.M. Schottker B. Brenner H. Serum 25-hydroxyvitamin D levels and survival in colorectal and breast cancer patients: Systematic review and meta-analysis of prospective cohort studies. Eur J Cancer. 2014; 50: 1510-1521 Abstract Full Text Full Text PDF PubMed Scopus (112) Google Scholar ]. However, the previous meta-analysis only pooled hazard ratios (HRs) with 95% confidence intervals (95%CIs) comparing highest with lowest categories of blood 25(OH)D levels, but it was still unclear whether there was a dose–response relationship between blood 25(OH)D levels and overall mortality in patients with colorectal cancer. Therefore, a dose–response meta-analysis was performed in the present study to assess the possible dose–response relationship in the association between blood 25(OH)D levels and overall mortality in patients with colorectal cancer.
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