Abstract
Background Dynamic gadolinium contrast-enhanced (DCE) vessel wall MRI has recently been used to compute a set of model-based contrast kinetic parameters (e.g. K and Vp) that can well characterize the extent of inflammation in carotid plaques [1,2]. However, no studies have shown its feasibility in coronary artery wall, presumably due to the technical challenges in imaging such a constantly-moving, ultra-small structure and potential difficulty in visually distinguishing the wall from the hyperintense lumen with conventional DCE techniques. This work aimed to develop a black-blood navigatorgated ECG-triggered T1-weighted sequence for DCE MRI of coronary vessel wall.
Highlights
Dynamic gadolinium contrast-enhanced (DCE) vessel wall MRI has recently been used to compute a set of model-based contrast kinetic parameters (e.g. Ktrans and Vp) that can well characterize the extent of inflammation in carotid plaques [1,2]
An SR-DIR preparation is combined with an RF spoiled GRE sequence to achieve: 1) To create T1weighting for vessel wall; 2) To consistently null the blood signal with a fixed inversion time combination (TI1 and TI2) (Fig. 1)
Bright-blood acquisition is interleaved with black-blood acquisition to enable arterial blood signal measurement as needed in kinetic modeling [3]
Summary
Dynamic gadolinium contrast-enhanced (DCE) vessel wall MRI has recently been used to compute a set of model-based contrast kinetic parameters (e.g. Ktrans and Vp) that can well characterize the extent of inflammation in carotid plaques [1,2]. No studies have shown its feasibility in coronary artery wall, presumably due to the technical challenges in imaging such a constantly-moving, ultra-small structure and potential difficulty in visually distinguishing the wall from the hyperintense lumen with conventional DCE techniques. This work aimed to develop a black-blood navigatorgated ECG-triggered T1-weighted sequence for DCE MRI of coronary vessel wall
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
