Abstract
The first study concerned with the determination of ezetimibe EZE in presence of its alkaline degradation product were developed and validated using different chemometric techniques [bivariate, classical least square (CLS), and principle component regression (PCR), partial least square (PLS)], with kinetic study and calculation of half-life time and activation energy which essential for quality control of its product. Application of the suggested techniques were successfully applied in synthetic mixture and in pharmaceutical preparations, the results obtained by the proposed techniques were statistically comparable with those obtained by the reported method. All the proposed techniques were validated according to international conference on harmonization (ICH) guidelines.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: Journal of Analytical & Pharmaceutical Research
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.