Abstract
The first study concerned with the determination of ezetimibe EZE in presence of its alkaline degradation product were developed and validated using different chemometric techniques [bivariate, classical least square (CLS), and principle component regression (PCR), partial least square (PLS)], with kinetic study and calculation of half-life time and activation energy which essential for quality control of its product. Application of the suggested techniques were successfully applied in synthetic mixture and in pharmaceutical preparations, the results obtained by the proposed techniques were statistically comparable with those obtained by the reported method. All the proposed techniques were validated according to international conference on harmonization (ICH) guidelines.
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