Abstract
BackgroundThe current increase of obesity and metabolic syndrome (MS) focuses attention on bisphenol-A (BPA), “obesogen” endocrine disruptor, main plastic component. Aim was to verify the role of BPA in metabolic alterations, insulin resistance, low grade inflammation and visceral obesity.MethodsA cross-sectional study was performed in 76 out of 139 environmentally exposed adult males, unselected Caucasian subjects, enrolled by routine health survey at the “Federico II” University of Naples outpatient facilities. BPA plasma levels (ELISA), metabolic risk factors, homeostasis model assessment of insulin resistance index, plasma monocyte chemoattractant protein 1, interleukin-6 (IL-6) and tumor necrosis factor-alpha were performed. Clinical and biochemical parameters have been compared with BPA and pro-inflammatory cytokines levels.ResultsIn total 24 subjects out of 76 (32%) presented with waist circumference (WC) >102 cm, 36 (47%) had impaired fasting glucose and 24 (32%) subjects had insulin resistance [11 out 52 (21%) with WC ≤102 cm and 13 out of 24 with WC >102 cm (54%), χ2 6.825, p = 0.009]. BPA and pro-inflammatory cytokine levels were significantly higher in subjects with visceral adiposity (WC > 102 cm). BPA correlated with WC, triglycerides, glucose homeostasis and inflammatory markers. At the multivariate analysis WC and IL-6 remained the main predictors of BPA.ConclusionsDetectable BPA plasma levels have been found also in our population. The strictly association between BPA and WC, components of MS, and inflammatory markers, further supports the BPA role in visceral obesity-related low grade chronic inflammation.
Highlights
The current increase of obesity and metabolic syndrome (MS) focuses attention on bisphenol-A (BPA), “obesogen” endocrine disruptor, main plastic component
According to Body mass index (BMI) cut off points, 36 subjects presented with normal weight, 28 were overweight and 12 had class I obesity
SBP, DBP, insulin, HoMA-insulin resistance (IR), IL-6 and TNFα were expressed an median with range
Summary
The current increase of obesity and metabolic syndrome (MS) focuses attention on bisphenol-A (BPA), “obesogen” endocrine disruptor, main plastic component. Aim was to verify the role of BPA in metabolic alterations, insulin resistance, low grade inflammation and visceral obesity. Obesity epidemics are responsible for the enormous strains on our health-care system, concerning economical aspects. BPA causes a widespread environmental human exposure via food and beverage containers, dental. Gender differences in serum/plasma BPA concentrations, possibly due to differences in the androgen-related metabolism of BPA, are well documented, with increase in the androgen-related glucuronidation by liver microsomes [18]. The BPA exposure is decreasing from consumer merchandise and by the substitution with bisphenol-S, an analog of BPA used in BPA-free products, is increasingly, BPA-free products containing BPS are not necessarily safer [19]
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