Biotribological behaviour, biodegradability and osteocompatibility of Mg-3Zn/HA composite based intramedullary inserts in avian model

Abstract

Bioactivity, structural integrity and tribological behaviour of biodegradable orthopaedic fracture fixing accessories considerably impact their actual performance in the body environment. Immune system in the living body quickly responds to the wear debris as foreign material and begins a complex inflammatory response. Magnesium (Mg) based biodegradable implants are widely studied for temporary orthopaedic applications, due to their similar elastic modulus and density to natural bones. However, Mg is highly vulnerable to corrosion and tribological damage in actual service conditions. To address these challenges via a combined approach, the Mg-3 wt% Zinc (Zn)/x hydroxyapatite (HA, x = 0, 5 and 15 wt%) based composites (fabricated via spark plasma sintering route) are evaluated in terms of biotribocorrosion and in-vivo biodegradation and osteocompatibility behaviour in an avian model. The addition of 15 wt% HA in the Mg-3Zn matrix has significantly enhanced the wear and corrosion resistance in the physiological environment. X-ray radiograph analysis of the Mg-HA-based intramedullary inserts implanted in the humerus bone of birds showed consistent progression of degradation and positive tissue response up to 18 weeks. The 15 wt% HA reinforced composites have shown better bone regeneration properties than other inserts. This study provides new insights into developing next-generation Mg-HA-based biodegradable composites for temporary orthopaedic implants, with excellent biotribocorrosion behaviour.