Abstract

Knowledge of statistics is essential for understanding the evidence from clinical trials. In this paper, the principles of blinding, FAS-ITT, pre-specified endpoints, subgroup analysis, missing values, sample size computation, applicability of global studies, non-inferiority trials, and meta-analysis are described. Moreover, the statistical aspects of the recent large-scale clinical trial regarding aducanumab as an Alzheimer's disease treatment will be discussed.

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