Abstract
A two-step cyclocondensation reaction has been carried out using 2-aminophenol with 2-chloroacetyl chloride to produce o-hydroxyphenyl chloroacetamide followed by treatment with KSCN in CH3COCH3 to produce the heterocyclic ligand 3-(2-hydroxyphenyl)-2-iminothiazolidin-4-one. The Zn2+ and Cd2+ complexes with a metal : ligands ratio of 1 : 4 were synthesized in ethanol using respective metal precursors with the title ligand. Antimicrobial activities of the ligand and its complexes were checked against some bacterial and fungal strains. The result evidenced better bioactive performance of the metal complex (though lower than the standard drug) than the free ligand against Escherichia coli, Staphylococcus aureus, and Salmonella typhi bacteria, as well as Fusarium oxysporum and Aspergillus niger fungal strains. Theoretical investigations on ligand and metal complexes help to infer the electronic structure behavior of them. Molecular geometry and bond order analysis provides detailed information on the nature of chemical structure and bonding. Molecular Electrostatic Potential (MEP) and atomic charge analysis claims evidence on charge distribution and electrophilic, nucleophilic reactive sites. Natural bond orbital analysis provides second-order perturbed stabilization interactions, orbital population, and their energies. Other theoretical properties such as hardness, softness, electron affinities, and ionization potential were derived and discussed in detail.
Highlights
In terms of structural and coordination compound chemistry, most metal complexes containing many heteroatoms in a membered ring receive a lot of attention
Escherichia coli, Staphylococcus aureus, and Salmonella typhi bacteria were transferred from the culture and streaked for 24 hours at 37°C on Mueller-Hinton agar (MHA) plates. e bacteria were transferred to autoclaved MHA that had been cooled to 45 degrees Celsius in a water bath and mixed vigorously by swirling the flasks
We reported the synthesis of L1 and its metal complexes with Zn and Cd metal
Summary
In terms of structural and coordination compound chemistry, most metal complexes containing many heteroatoms in a membered ring receive a lot of attention. Imines are nitrogen carbon double bond compounds owing to their stability and structural similarity to natural biological substances; imines are an essential class of compounds and are used as antipathogenic agents (bacteria, fungal) of which thiazolidinone are derivatives, which play an important role in medical science, and their unique physicochemical properties, which allow them to be used in a variety of other fields, put them ahead of other heterocyclic organics [2]. These compounds function as well-liked ligands, and their biosensitivity has been shown to increase with complexation.
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