Abstract
The combination of biodegradable polymers and bioactive inorganic materials is a promising method to mimic native tissue in bone regeneration. Toward this direction, electrospun fibrous scaffolds were successfully fabricated in the silk fibroin (SF) matrix containing new bioceramics on the basis of mesoporous bioactive glass/hydroxyapatite nanocomposite (MGHA). The physicochemical properties and surface hydrophilicity of these biphasic composite could be tailored by the addition of MGHA content. The increase in surface hydrophilicity and bioactivity of the as-spun composite fibers were observed with the increasing the nanoparticle contents while decreasing their tensile strength. In vitro cytotoxicity evaluation based on human bone marrow-derived mesenchymal stem cells (hMSCs) revealed that a positive osteogenic differentiation effect on SF/MGHA7 sample as evidenced by an increased alkaline phosphatase (ALP) activity, and upregulated osteoblastic gene expression compared with SF samples. These findings supported the suitability of the SF/MGHA composite system for its potential application in cell–material combination in bone tissue engineering.
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