Abstract
Uterine contractions are generated by myometrial smooth muscle cells (SMCs) that comprise most of the myometrial layer of the uterine wall. Aberrant uterine motility (i.e., hypo- or hyper-contractility or asynchronous contractions) has been implicated in the pathogenesis of infertility due to the failure of implantation, endometriosis and abnormal estrous cycles. The mechanism whereby the non-pregnant uterus initiates spontaneous contractions remains poorly understood. The aim of the present study was to employ linear synchronization measures for analyzing the pattern of EMG signal propagation (direction and speed) in smooth muscles of the non-pregnant porcine uterus in vivo using telemetry recording system. It has been revealed that the EMG signal conduction in the uterine wall of the non-pregnant sow does not occur at random but it rather exhibits specific directions and speed. All detectable EMG signals moved along the uterine horn in both cervico-tubal and tubo-cervical directions. The signal migration speed could be divided into the three main types or categories: i. slow basic migration rhythm (SBMR); ii. rapid basic migration rhythm (RBMR); and iii. rapid accessory migration rhythm (RAMR). In conclusion, the EMG signal propagation in smooth muscles of the porcine uterus in vivo can be assessed using a linear synchronization model. Physiological pattern of the uterine contractile activity determined in this study provides a basis for future investigations of normal and pathologicall myogenic function of the uterus.
Highlights
Uterine contractions are generated by myometrial smooth muscle cells (SMCs) comprising most of the myometrial layer of the uterine wall
In a previous study [21] we demonstrated the usefulness of the cross-coherence function in synchronization between uterine horn and corpus uteri for multiple action potentials in short time measurement (
We suggested to divide the propagation speed uterus into one of three distinctive categories: slow and rapid basic migration rhythm (SBMR, RBMR) and rapid accessory migration rhythm (RAMR)
Summary
Uterine contractions are generated by myometrial smooth muscle cells (SMCs) comprising most of the myometrial layer of the uterine wall. Synchronous contractions of SMCs are responsible for normal gamete transport in the female reproductive tract and contribute to the expulsion of uterine debris [1]. The occurrence of uterine contractions must be strictly controlled and coordinated to sustain these reproductive functions [1, 2]. Abnormal patterns of uterine motility such as hypoactive, hyperactive or asynchronous contractions have been. Biomathematical pattern of EMG signal in smooth muscle of the non-pregnant porcine uterus
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