Abstract
The biotransformation of 4-propylcyclohexanone and 4-isopropylcyclohexanone was examined using ten different anthracnose fungi as biocatalysts. 4-Propylcyclohexanone and 4-isopropylcyclohexanone were reduced to the corresponding cis- and trans-alcohols, respectively, and transformed mainly to trans-4-alcohols by all ten fungi enumerated as follows; Colletotrichum lagenarium, C. dematium MAFF410046, C. trifolii MAFF305389, C. fragariae, C. atramentarium MAFF712102, C. lindemuthianum (C-1), C. lindemuthianum (C-3), C. lindemuthianum (C-13), C. graminicola MAFF305460 and Glomerella cingulata. In particular, the ratio of cis- and trans-alcohol products was shown to be 1 : 13 (4-propylcyclohexanol) and 1 : 11 (4-isopropylcyclohexanol) with high stereoselectivity by C. lagenarium after a 7-day incubation period.
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