Abstract
With the COVID-19 pandemic causing huge threat to public health and definite treatment modalities and preventive vaccines yet to be arrived at, some of the key indicators of relevance to its prognosis have started emerging. One such independent predictor of outcome has been fasting plasma glucose (FPG) at the time of admission. Earlier, co-morbidities such as diabetes also have been reported to have a risk of relatively increased mortality due to COVID-19. In this background, we herein report on the beneficial effects of Biological response modifier glucan (BRMG) secreted by the black yeast Aureobasidium pullulans AFO-202 which has been proven to bring under control blood sugar levels in human subjects and also has potential in enhancing & regulating the immune parameters in relevance to COVID-19. We further recommend that this BRMG be tried in clinical studies of COVID-19 to provide a prophylactic effect for validation.
Highlights
Fasting plasma glucose (FPG) level at admission has been indicated as a strong independent predictor of mortality in COVID19 affected patients [1.2]
Zhang et al reported about 461 COVID-19 patients in whom fasting plasma glucose (FPG) level ≥ 6.23 mmol/L at admission was a strong independent predictor of poor outcomes
Beyond acting on blood glucose levels, this AFO-202 Biological response modifier glucan (BRMG) has been indicated as worthwhile to be considered for clinical trials in COVID-19 patients due to its balanced immune enhancement by decreasing hyperinflammation factors such as IL-6 that lead to cytokine storms; increasing IFN-γ, sFAS, and factors like IL-7; and enhancing anti-viral cytotoxic immunity, as mediated by T cells, NK cells, macrophages, and antibody production by B cells [17]
Summary
Fasting plasma glucose (FPG) level at admission has been indicated as a strong independent predictor of mortality in COVID19 affected patients [1.2]. Beyond acting on blood glucose levels, this AFO-202 BRMG has been indicated as worthwhile to be considered for clinical trials in COVID-19 patients due to its balanced immune enhancement by decreasing hyperinflammation factors such as IL-6 that lead to cytokine storms; increasing IFN-γ, sFAS, and factors like IL-7; and enhancing anti-viral cytotoxic immunity, as mediated by T cells, NK cells, macrophages, and antibody production by B cells [17]. With Zhang et al [2] having reported that high FPG level is a precipitating factor leading to poor COVID-19 outcomes, this BRMG has gained further significance as a prophylactic agent whose continuous supplementation has been proven to balance FPG levels They play a vital role by both enhancing individuals’ immune capabilities to tackle COVID-19 infection and downregulating the factors responsible for hyperinflammation leading to cytokine storms, thereby preventing morbidity and mortality. It is interesting to specify that the beneficial effects of the AFO-202 BRMG as a prophylactic supplement to help combat coagulopathy associated with COVID-19, especially in vulnerable people like those with diabetes has been recently published [27]
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