Abstract
Biological noise to get a sense of direction: an analogy between chemotaxis and stress response
Highlights
From the earliest studies on bacteria (Spudich and Koshland, 1976; Elowitz et al, 2002), it was soon understood that biological processes are often dominated by the stochasticity that pervades the physical world
Combining the two types of motion, evolution has selected a strategy that allows bacteria to explore their environment in search for food, performing what is effectively a random walk biased by the concentration field
STRESS RESPONSE VARIABILITY AS MAPPING IN TIME stress response in cells is similar to chemotaxis, in the sense that predicting in which direction to go to get to the food corresponds to a yeast population deciding on whether growth conditions are going to get better or worse
Summary
From the earliest studies on bacteria (Spudich and Koshland, 1976; Elowitz et al, 2002), it was soon understood that biological processes are often dominated by the stochasticity that pervades the physical world. Even at the tissue level, the presence of fluctuations in time and across cellular populations serves as a detection tool that ensures fast reaction to any changes in the tissue’s condition (Paszek et al, 2010; Levine et al, 2013).
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