Abstract
The use of Ru complexes in light-mediated treatment of cancer (i.e. Photodynamic Therapy – PDT) has recently become extremely relevant with the entry into clinical trials of the first complex of this class against bladder cancer in the very near future. Herein, we report on the potential application as PDT agents of two inert Ru(II) polypyridyl complexes bearing a nitrile containing dppz ligand and two bipy or phen ancillary ligands for 1 and 2, respectively (dppz=dipyrido[3,2-a:2′,3′-c]phenazine, bipy=2,2′-bipyridine, phen=1,10-phenathroline). More specifically, a full characterization of the novel compound 2 was first performed. The distribution coefficients (log D) and 1O2 quantum yields in two solvent systems and at two irradiation wavelengths were then determined for both compounds. The phototoxicity of complexes 1 and 2 was evaluated on cervical cancer HeLa cells and on non tumorigenic retinal pigment epithelial (RPE1-hTERT) cells. None of the complexes was found to be phototoxic. In vitro fluorescence microscopy indicated a scarce cellular uptake for 2. The lack of biological activity for complexes 1 and 2 highlights that more investigations are required in order to understand the relationship between structure and biological activity for this class of compounds.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
